Doxcycle files will not create or open from their taxcycle doxcycle buttons if doxcycle process is not already open.
Uninstalled both Doxcycle and Taxcycle and then reinstalled. Did not fix the issue.
Should note that if I use the Link tab, source documents, Doxcycle will open using the link there.
After rebooting my computer with each uninstalls and reinstalls I was still having the above problem. So I figured one more reboot wasn’t going to hurt anything and that final reboot worked.